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Fig. 7 | BMC Neuroscience

Fig. 7

From: Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury

Fig. 7

Altered Spp1 expression affects cytokine expression and c-Fos, PKCα and p-ERK/ERK pathways in vivo. a Real-time qPCR analysis of Spp1, bax, bcl2, NT3, PKCα and EGR2 expression levels after exposure of injured rat sciatic nerves to Spp1 siRNA-858 for 1 and 2 weeks. GAPDH levels were used as a control (*p < 0.05). The average of three independent experiments is shown as mean ± SEM. b Western blot analysis of Spp1, c-Fos, p-ERK/ERK, and PKCα protein expression levels after injured rat sciatic nerves were exposed to Spp1 siRNA-858 for 1 and 2 weeks. GAPDH levels were used as a control (*p < 0.05). cf Relative protein expression levels of Spp1, c-Fos, p-ERK/ERK, and PKCα as determined by Western blot analysis. The average of three independent experiments is shown as mean ± SEM (*p < 0.05)

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