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Fig. 2 | BMC Neuroscience

Fig. 2

From: Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze

Fig. 2

Representative images showing cholinergic lesions after the injection of 192 IgG-saporin. a Atlas schematic showing the medial septum. The square indicates the location at which the images were taken. b The normal group exhibited a large number of choline acetyltransferase (ChAT)-immunopositive neurons (red) in the medial septum. The lesion groups (c) and all the stimulation groups (d pre-stimulation, e training-stimulation, f probe-stimulation), which were all injected with 192 IgG-saporin, exhibited a loss of ChAT-immunopositive neurons. g The number of ChAT-immunopositive neurons was significantly reduced by 192 IgG-saporin (p < 0.05)

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