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Fig. 3 | BMC Neuroscience

Fig. 3

From: Early start of progressive motor deficits in Line 61 α-synuclein transgenic mice

Fig. 3

Expression of synuclein in Line 61 mice. A A representative section shows expression of transgenic human α-Syn in a male Line 61 mouse at 9 months of age. The transgene is ubiquitously present in gray matter with very high expression levels in the isocortex (red channel). B, C Magnified single channel images of the hippocampal CA1 region show high human α-Syn levels in a subset of pyramidal cell somata (arrows, B), and most of these show immunoreactivity for phosphorylated pSer129-α-Syn (C). D, E The overall morphology of the brain is normal, without any obvious occurrence of cell loss in CA1 (NeuN green; DAPI blue). FI Immunofluorescent labeling in 7-months old Line 61 mice for total Syn using a pan-specific antibody (α/β/γ-Syn, murine and human), myelinated axons (CNPase green), and DAPI. CX cortex, CPu corpus putamen, HC hippocampus, sl stratum lucidum, so stratum oriens, sp stratum pyramidale, sr stratum radiatum. Scale bar A 500 µm; F, H 1000 µm; BE, G, I 50 µm

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