TY - JOUR AU - You, Fuling AU - Li, Qiao AU - Jin, Guifang AU - Zheng, Yaojie AU - Chen, Jingrong AU - Yang, Hong PY - 2017 DA - 2017/01/12 TI - Genistein protects against Aβ25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers JO - BMC Neuroscience SP - 12 VL - 18 IS - 1 AB - Deposition of aggregated amyloid beta (Aβ) protein is hallmark of Alzheimer’s disease, leading to dysfunction and apoptosis of neurons. The isoflavone phytoestrogen compound genistein (Gen) exerts a significant protective effect against Aβ25–35 induced neurotoxicity and mitochondrial damage in rat pheochromocytoma (PC12) cells. However, the mechanisms underlying Gen’s rescue remain elusive. Therefore we endeavored to research further the molecular mechanisms underlying Gen’s inhibition of Aβ25–35 induced apoptosis of neurons. SN - 1471-2202 UR - https://doi.org/10.1186/s12868-016-0329-9 DO - 10.1186/s12868-016-0329-9 ID - You2017 ER -