Skip to main content
Fig. 5 | BMC Neuroscience

Fig. 5

From: Neural hyperactivity in the amygdala induced by chronic treatment of rats with analgesics may elucidate the mechanisms underlying psychiatric comorbidities associated with medication-overuse headache

Fig. 5

Cortical spreading depression-evoked Fos-immunoreactive neurons in the central nucleus of the amygdala from rats chronically treated with acetaminophen or aspirin, and from saline-treated control rats (scale bar 250 μm in each section and 50 μm in the inset). a Ipsilateral control, b ipsilateral chronic acetaminophen, c ipsilateral chronic aspirin, d contralateral control, e contralateral chronic acetaminophen and f contralateral chronic aspirin. The graph presents a statistical analysis of Fos-immunoreactive neurons (mean ± SD of counts per slide from 10 rats). *P < 0.05 compared with neurons in the amygdala of saline-treated control rats, one-way ANOVA followed by a Dunnett test

Back to article page