Fig. 4

Trans-UCA applied topically in combination with UVB is not as effective as UVB alone to suppress EAE. a Topical trans-UCA significantly increases skin trans content. Despite this, when combined with UVB, supplemental trans is converted to cis to levels similar to that in animals exposed to UVB alone. b UVB alone is the only group in which spleen:body weight ratio was significantly increased (P < 0.03). Error bars are SD from the Mean and represent biological variation. c Trans-UCA alone does not affect disease course. UVB greatly suppresses EAE onset and progression. When supplemental trans-UCA is given topically prior to UVB exposure, the disease suppression is dampened. Data are cumulative of two independent experiments