Fig. 6From: Important modifications by sugammadex, a modified γ-cyclodextrin, of ion currents in differentiated NSC-34 neuronal cellsEffect of SGX treatment on voltage-gated Na+ current (I Na) in differentiated NSC-34 cells. The untreated and SGX-treated cells were bathed in Ca2+-free Tyrode’s solution. I Na was evoked in response to membrane depolarization from −80 to −10 mV. a Superimposed I Na tracings obtained in the cell without (a) and with (b) the exposure to SGX (30 μM). I Na trace labeled (c) was obtained after addition of ranolazine (10 μM) in SGX-treated cells. The inset indicates an expanded record from dashed box. Notably, I Na amplitude obtained from untreated and SGX-treated cells did not differ significantly; however, ranolazine could effectively suppress I Na recorded from SGX-treated cellsBack to article page