TY - JOUR AU - Siegert, Elise AU - Paul, Friedemann AU - Rothe, Michael AU - Weylandt, Karsten H. PY - 2017 DA - 2017/01/24 TI - The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice JO - BMC Neuroscience SP - 19 VL - 18 IS - 1 AB - There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function. Some studies have shown that these PUFAs might have a beneficial effect in patients suffering form multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system (CNS). This could be due to increased n-3 PUFA-derived anti-inflammatory lipid mediators. In the present study we tested the effect of an endogenously increased n-3 PUFA status on cuprizone-induced CNS demyelination and remyelination in fat-1 mice versus their wild-type (wt) littermates. Fat-1 mice express an n-3 desaturase, which allows them to convert n-6 PUFAs into n-3 PUFAs. SN - 1471-2202 UR - https://doi.org/10.1186/s12868-016-0312-5 DO - 10.1186/s12868-016-0312-5 ID - Siegert2017 ER -