From: mTOR and MAPK: from localized translation control to epilepsy
 | Effect | Pathway | Epilepsy related targets | Link to epilepsy | |
---|---|---|---|---|---|
Gene | Protein | ||||
FMRP | Translational repression and dendritic RNA transport [48] | CaMKIIα | |||
KCNC1 | Kv3.1 [52] | ||||
KCND2 | Kv4.2 [54] | ||||
CACNA1B | Cav2.2 [53] | Audiogenic seizures in rats with FXS [62] | |||
KCNMA1 | BK channel [51] | ||||
KCNT1 | Slack channel [50] | ||||
HuD | RNA stabilization | CaMKIIα | CaMKIIα [77] | Increased protein level in rats with kainate induced seizures [70] | |
Splicing control | KCNA1 | Kv1.1 [69] | |||
Neuronal differentiation and plasticity [67] | GLS | Glutaminase [73] | Increased susceptibility to audiogenic seizures in mice [28] | ||
HuR | RNA stabilization | GAP-43 | Pentylenetetrazol-induced seizures in mice [82] | ||
Splicing control [86] | |||||
Cellular stress response [67] | |||||
CREB | Translational activator [89] | MAPK [40] | Bdnf | Epileptic seizures in animal models of epilepsy and human patients [29] |