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Table 1 Epilepsy targets that are regulated by RBPs and dependent on mTOR/MAPK activity

From: mTOR and MAPK: from localized translation control to epilepsy

  Effect Pathway Epilepsy related targets Link to epilepsy
Gene Protein
FMRP Translational repression and dendritic RNA transport [48] mTOR [5761] CaMKIIα CaMKIIα [20, 48] Childhood seizures in patients and mice with FXS [27, 56]
MAPK [20, 62, 65] KCNC1 Kv3.1 [52]
KCND2 Kv4.2 [54]
CACNA1B Cav2.2 [53] Audiogenic seizures in rats with FXS [62]
KCNMA1 BK channel [51]
KCNT1 Slack channel [50]
HuD RNA stabilization mTOR [76, 77, 79] CaMKIIα CaMKIIα [77] Increased protein level in rats with kainate induced seizures [70]
Splicing control MAPK [76, 80] KCNA1 Kv1.1 [69]
Neuronal differentiation and plasticity [67] GLS Glutaminase [73] Increased susceptibility to audiogenic seizures in mice [28]
HuR RNA stabilization MAPK [8285] GAP-43 GAP-43 [68, 72] Pentylenetetrazol-induced seizures in mice [82]
Splicing control [86]
Cellular stress response [67]
CREB Translational activator [89] MAPK [40] Bdnf BDNF [29, 92] Epileptic seizures in animal models of epilepsy and human patients [29]
  1. RBPs, their general effect on gene expression, involvement in mTOR and/or MAPK pathways, their mRNA targets, and encoded proteins as well as their link to epilepsy in animal models and human patients are depicted