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Table 1 Epilepsy targets that are regulated by RBPs and dependent on mTOR/MAPK activity

From: mTOR and MAPK: from localized translation control to epilepsy

 

Effect

Pathway

Epilepsy related targets

Link to epilepsy

Gene

Protein

FMRP

Translational repression and dendritic RNA transport [48]

mTOR [57–61]

CaMKIIα

CaMKIIα [20, 48]

Childhood seizures in patients and mice with FXS [27, 56]

MAPK [20, 62, 65]

KCNC1

Kv3.1 [52]

KCND2

Kv4.2 [54]

CACNA1B

Cav2.2 [53]

Audiogenic seizures in rats with FXS [62]

KCNMA1

BK channel [51]

KCNT1

Slack channel [50]

HuD

RNA stabilization

mTOR [76, 77, 79]

CaMKIIα

CaMKIIα [77]

Increased protein level in rats with kainate induced seizures [70]

Splicing control

MAPK [76, 80]

KCNA1

Kv1.1 [69]

Neuronal differentiation and plasticity [67]

GLS

Glutaminase [73]

Increased susceptibility to audiogenic seizures in mice [28]

HuR

RNA stabilization

MAPK [82–85]

GAP-43

GAP-43 [68, 72]

Pentylenetetrazol-induced seizures in mice [82]

Splicing control [86]

Cellular stress response [67]

CREB

Translational activator [89]

MAPK [40]

Bdnf

BDNF [29, 92]

Epileptic seizures in animal models of epilepsy and human patients [29]

  1. RBPs, their general effect on gene expression, involvement in mTOR and/or MAPK pathways, their mRNA targets, and encoded proteins as well as their link to epilepsy in animal models and human patients are depicted