Fig. 3

Rapid, shallow breathing in AAV9 FUS rats at end stage. a Representative plethysmography tracings of 5 s of respiration in a FUS rat at pre-injection and end stage (week 0 and week 5). b Respiratory frequency was increased in the FUS group at end stage (p < 0.001). c Tidal volume was decreased in FUS rats at end stage (p < 0.01). d Minute ventilation was significantly increased at end stage in FUS rats (p < 0.01). e The vehicle group showed increased inspiratory time over 8 weeks (p < 0.05); whereas, the FUS group showed decreased inspiratory time at end stage (p < 0.001). f Expiratory time was increased in the vehicle group after 8 weeks (p < 0.01) and decreased in the FUS group (p < 0.001). g Total respiratory time was increased in the vehicle group (p < 0.05) and decreased in the FUS group (p < 0.001). The n in b–g is 4–6/group as indicated in b. Asterisk indicates p < 0.05