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Fig. 7 | BMC Neuroscience

Fig. 7

From: Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy

Fig. 7

Images of coronal sections of the hippocampus stained with NeuN antibody (red) as a neuronal marker and GFAP antibody (green) as an astrocytes marker showing the progression of microgliosis over the course of time (1 day, 3 days, 1 week and 2 weeks) in the dentate gyrus and CA3 of the hippocampus of adrenalectomized rats compared to sham operated rats. Absence of astrogliosis was noticed in the dentate gyrus (A, B, C, D) and CA3 (E, F, G, H) of sham operated rats during the different time points (1 day, 3 days, 1 week and 2 weeks). 1 day and 3 days after adrenalectomy the rats showed no signs of astrogliosis in the dentate gyrus (A’, B’) and CA3 (E’, F’) respectively. A progression of astrogliosis was seen in the dentate gyrus after 1 week (C’) and 2 weeks (D’) whilst no immunoreactivity was seen in CA3 after 1 week (G’). However appearance of astrogliosis in CA3 was seen after 2 weeks (D’). Molecular layer (ML), granule cell layer (GCL), polymorphous layers (PL) and (SL) stratum lucidum. Scale bar 50 µm

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