Skip to main content
Fig. 5 | BMC Neuroscience

Fig. 5

From: Increased pro-inflammatory cytokines, glial activation and oxidative stress in the hippocampus after short-term bilateral adrenalectomy

Fig. 5

Images of coronal sections of the hippocampus stained with NeuN antibody (red) as a neuronal marker and Iba-1 antibody (green) as a microglia marker showing the progression of microgliosis over the course of time (1 day, 3 days, 1 week and 2 weeks) in the dentate gyrus and CA3 of the hippocampus of adrenalectomized rats compared to sham operated rats. Absence of microgliosis in the dentate gyrus (A, B, C, D) and CA3 (E, F, G, H) of sham operated rats during 1 day, 3 days, 1 week and 2 weeks. The adrenalectomized rats showed no signs of microgliosis in the dentate gyrus (A’) and CA3 (E’) after 1 day. However, a progression of microgliosis was seen in the dentate gyrus after 3 days (B’), 1 week (C’) and 2 weeks (D’). In comparison, the microgliosis in the CA3 of adrenalectomized rats did not appear until after 2 weeks as the Iba1 immunoreactivity after 1, 3 days and 1 week was not significantly different from that in sham operated rats. Molecular layer (ML), granule cell layer (GCL), polymorphous layers (PL) and (SL) stratum lucidum. Scale bar 50 µm

Back to article page