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Fig. 7 | BMC Neuroscience

Fig. 7

From: Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer’s disease

Fig. 7

Effects of PICALM siRNA targeting isoforms 1 and 2 of PICALM on APP processing. Levels of a APP and b βCTF in H4 cells, as detected by ELISA following incubation with media, or siRNA targeting either total PICALM (sequence A), PICALM isoform 1, PICALM isoform 2 or GFP for 48 h. Data are expressed as % of media control and are mean ± SEM, *p < 0.01, ***p < 0.001 significantly different to GFP siRNA with a one-way analysis of variance and Dunnett’s multiple comparison test, n = 5 (a) and, n = 4–5 (b)

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