Fig. 6
From: Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke
Model of PSC development in the post-natal brain and as a source of RA following stroke injury. Potential model of how during post-natal brain development Col1a1+ cells (putative PSCs) could ‘move’ from the meningeal space to the perivascular space around large diameter blood vessels via Virchow-Robin Spaces (A). Following injury Raldh1+ macrophages/microglia and Raldh1/2+ PSCs within the ischemic core produce RA capable of activating RA signaling in adjacent peri-infarct astrocytes and neurons (B)