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Fig. 2 | BMC Neuroscience

Fig. 2

From: Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke

Fig. 2

Expression of perictye and meningeal cell markers changes over maturation and post-injury activation of PSCs. Confocal images on sections from hippocampus (P0), thalamus or midbrain (P21) and cerebral cortex or striatum (MCAO) with antibodies that label pericytes and/or meningeal cells to characterize Col1a1+ PSC marker expression. Col1a1+ PSCs (green, A–C) express PDGFrβ (red, A–C) at P0 and P21 and in the post-MCAO lesion (arrows, A–C). At P0 and P21, PDGFrβ is also expressed by perivascular pericytes that do not have Col1a1 expression (carets, A, B). CoupTF2 (red, DF) is expressed by Col1a1+ (green, D, E) PSCs surrounding IB4+ blood vessels at P0 and P21 (arrows, D, E) and by PDGFβ+ PSCs (green, F) in the stroke lesion (arrows, F). Carets in D indicate CoupTF2 +/Col1a1+ cells in the meninges. IB4 in F also labels macrophages (blue, caret). PDGFrα is expressed in the meninges (red, carets, G, H), is weakly expressed by Col1+ PSCs at P0 (green, open-arrows, G) but is strongly expressed by these cells at P21 (arrows, H) and in the stroke lesion (arrows, I). IB4 (blue) labels blood vessels and microglia/macrophages in A, DH and DAPI (blue) marks nuclei in I. Scale bars 100 μm

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