Skip to main content
Fig. 5 | BMC Neuroscience

Fig. 5

From: Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

Fig. 5

Hematoxylin and Eosin staining of APP, APP + PS1, and WT rat brains. 4× magnification of a hippocampus section from an APP (a), APP + PS1 (b), and WT rat (c). CA1, CA2, CA3 regions of the hippocampus and dentate gyrus (DG) are labeled in c. Panels dr show 60X magnification of the brain and each arrow style represents similar pathology throughout the figure. d APP CA1 region with necrotic and dark colored pyramidal neurons (black arrowhead), ghost tangles (white arrow), and normal looking neurons (white arrow head). e APP + PS1 CA1 showing degeneration with condensed Nissl substance (grey arrow) and chromatolysis (grey arrow head). f WT CA1. g APP CA2 with neurofibrillary tangles in viable neurons with visible nuclei (black arrow) and non-viable neurons (black arrow with white outline) and ghost tangles. h APP + PS1 CA2 showing chromatolysis in neurons. i WT CA2. j APP CA3 with neurofibrillary tangles and condensed Nissl substance. k APP + PS1 CA3 with neurofibrillary tangles. l WT CA3. m APP DG granule cells with condensed Nissl substance and necrotic cells. n APP + PS1 DG with necrotic cells and neurofibrillary tangles. o WT DG. p, q APP and APP + PS1 cortex neurons with condensed Nissl substance, neurofibrillary tangles, necrotic neurons, and ghost tangles. r WT cortex

Back to article page