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Fig. 1 | BMC Neuroscience

Fig. 1

From: Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

Fig. 1

a Southern blot analysis of the genomic DNA of the founder animals used to determine the copy number of PS1 transgene. The copy number of the PS1 transgene was determined by the number of hybridized genomic DNA segments in the autoradiogram and is shown in parenthesis above the rat numbers. M represents the molecular weight (MW) markers. b Serum Aβ42/Aβ40 levels of APP + PS1 double transgenic founder animals and APP21 rats at 8 weeks of age. The Aβ42/Aβ40 ratio for rat 988 could not be determined because its Aβ42 level was lower than the detection limit of the test. Founder 964 was selected based on having one PS1 transgene and high Aβ42/Aβ40 levels as well as for having a large litter with high Aβ42/Aβ40 levels

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BMC Neuroscience

ISSN: 1471-2202

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