Fig. 4

Influence of intransally administered A-beta peptides on Morris water maze task in C57B6/J mice. a Learning during training days one to five is displayed by the time to find the submerged platform for mice treated with A-beta 42 peptides (closed circles, n = 10) or with solvent (open circles, n = 14) Significant daily differences (Student’s t test) are indicated by *(p < 0.05) and ***(p < 0.001). b Memory related behavior based on crossing the former platform location or time spent in the quadrant searching the platform at the probe trial (day 6). Crossings are given as total numbers (Student’s t test; *p < 0.05, left part of the graph) and time spent in the respective quadrant (NE North East, SE South East, SW South West, NW North West) is given in % of total time (60 s). White bars represent group mean ± SEM of control-treated animals whereas black bars represent values obtained for A-beta 42 peptide treated animals (*p < 0.05; **p < 0.01, one-way ANOVA, Sidak’s multiple comparisons test; #p < 0.05 indicates dwell times above chance level (25 %) one sample t test)