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Fig. 1 | BMC Neuroscience

Fig. 1

From: The preventive effect of resiniferatoxin on the development of cold hypersensitivity induced by spinal nerve ligation: involvement of TRPM8

Fig. 1

Effect of resiniferatoxin (RTX) pretreatment on the withdrawal threshold to mechanical stimuli. Perineural administration of vehicle or RTX (0, 0.1, or 1 µg) was performed before spinal nerve ligatoin (SNL). Behavioral tests were performed before surgery and weekly for 4 weeks after SNL. To test mechanical hyperalgesia, a von Frey filament was used to stimulate the plantar surface of the ipsilateral left hind foot. The data are presented as the mean ± standard error. **P < 0.01 and ***P < 0.001 compared to the RTX 0 µg group

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BMC Neuroscience

ISSN: 1471-2202

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