Fig. 5

Effects of exendin-4 and liraglutide on MCAO-induced apoptosis-related protein expression. Typical western blots of Bax, B-cell lymphoma 2 (Bcl-2), caspase 3, poly-(ADP-ribose)-polymerase (PARP), and manganese superoxide dismutase (MnSOD) expression a and f phosphorylated Akt (p-Akt) and endothelial nitric oxide synthase (p-eNOS) levels b in the right cerebral cortex of sham-operated control or MCAO-injured db/db mice at 3, 6, or 12 h after surgery. Densitometric quantification of the ratio of Bax/Bcl-2 bands (b) and caspase 3 (c), PARP (d), MnSOD (e), p-Akt (g), and p-eNOS (h) bands normalized to β-actin. Data are presented as mean ± SEM (n = 6 per condition). Groups were compared using two-way ANOVA with a post hoc Bonferroni adjustment for pairwise comparisons. *P < 0.05 compared to control; ^a P < 0.05 compared to 3 h after MCAO; ^b P < 0.05 compared to 6 h after MCAO; ^# P < 0.05 compared to 12 h after MCAO