Skip to main content
Fig. 3 | BMC Neuroscience

Fig. 3

From: The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

Fig. 3

Effects of exendin-4 and liraglutide on MCAO-induced ROS production. Shown are DHE (a), blood ROS (b), brain ROS (c) and brain malondialdehyde (MDA) content (d) at 3, 6, and 12 h after MCAO injury in db/db mice. MCAO significantly increased DHE expression, blood and brain ROS levels, and brain MDA content, whereas exendin (Ex) and Lir partially occluded these effects. Data are presented as mean ± SEM (n = 6 per condition). Groups were compared using two-way ANOVA with a post hoc Bonferroni adjustment for pairwise comparisons. *P < 0.05 compared to controls; a P < 0.05 compared to 3 h after MCAO; b P < 0.05 compared to 6 h after MCAO; # P < 0.05 compared to 12 h after MCAO

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us