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Fig. 2 | BMC Neuroscience

Fig. 2

From: The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

Fig. 2

Effects of exendin-4 on MCAO-induced markers of oxidative stress, inflammation, and apoptosis. Shown are dihydroethidium (DHE) labeling of reactive oxygen species (ROS; a, f, k, p, u), intercellular adhesion molecule-1 (ICAM-1; b, g, l, q, v), DHE and ICAM-1 merged (c, h, m, r, w) caspase 3 (d, i, n, s, x, indicated by brown color) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL; e, j, o, t, y, indicated by brown color) at 3, 6, and 12 h after MCAO injury in db/db mice. MCAO markedly increased DHE, ICAM-1, Caspase 3 and TUNEL labeling; these effects were offset by Ex-4 treatment (magnification DHE, ICAM-1 400; and magnification Caspase3, TUNEL 200)

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BMC Neuroscience

ISSN: 1471-2202

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