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Fig. 1 | BMC Neuroscience

Fig. 1

From: The GLP-1 receptor agonists exendin-4 and liraglutide alleviate oxidative stress and cognitive and micturition deficits induced by middle cerebral artery occlusion in diabetic mice

Fig. 1

Effects of exendin-4 and liraglutide on cerebral microcirculation after injury in db/db mice. a Schematic diagram showing the area of microcirculation measurement. b Representative full field laser perfusion images showing cerebral microcirculation in mice treated with exendin-4 (Ex-4) or liraglutide (Lir) following middle cerebral artery occlusion (MCAO) injury. Percentage change in perfusion units (PU), presented as mean ± standard error of the mean (SEM; n = 6 per condition). Groups were compared using two-way analysis of variance (ANOVA) with a post hoc Bonferroni adjustment for pairwise comparisons. *P < 0.05 compared to the MCAO group. c The T2-weight magnetic resonance imaging series revealed that after MCAO 12 h group marked brain edema (hight signal intensity area) had a significantly higher percentage in the red line section area d in comparison with control group. e After Exendin-4 and Liraglutide treatment decrease the brain edema percentage more significantly than the group of MCAO. *P < 0.05 compared to the control group, a P < 0.05 compared to the MCAO group

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BMC Neuroscience

ISSN: 1471-2202

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