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Fig. 2 | BMC Neuroscience

Fig. 2

From: Neuroprotective effect of activated 5′-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation

Fig. 2

Anti-inflammatory effect of AICAR in the retina. a, b The retinal samples were obtained 1.5 h after lipopolysaccharide (LPS) injection and subjected to real-time polymerase chain reaction (PCR). a The mRNA level of Tnf-α was increased in the retina, and the increase was significantly suppressed by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) treatment. b The mRNA level of Pgc1-α in the retina was decreased in the endotoxin-induced uveitis (EIU) model, and this decrease was attenuated by AICAR. c Immunohistochemistry showing that the enhanced expression of glial fibrillary acidic protein (GFAP) in the retina 24 h after LPS injection was suppressed by AICAR treatment. a–c All groups, n = 6. a, b All results are expressed as the mean ± SD. One-way ANOVA with Tukey’s post hoc test was used to assess the statistical significance of differences. P < 0.05 was regarded as significant. *P < 0.05. **P < 0.01

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BMC Neuroscience

ISSN: 1471-2202

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