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Table 2 Rat seizure score

From: Histone deacetylase inhibitor SAHA attenuates post-seizure hippocampal microglia TLR4/MYD88 signaling and inhibits TLR4 gene expression via histone acetylation

 

No seizure

Stage 1

Stage 2

Stage 3

Stage 4

Stage 5

Mean score

KA

0

0

3

3

12

17

4.23 ± 0.94

KA + SAHA 10 mg/kg

3

1

6

4

11

11

3.44 ± 1.56*

KA + SAHA 50 mg/kg

6

4

9

11

5

3

2.37 ± 1.48***

  1. The rats in different seizures stage were counted and mean seizure score was analyzed by statistical method. Data are expressed as mean values ± SD
  2. * P < 0.05; *** P < 0.001, as compared with the KA-treated group