Table 1 Upstream regulators in hypothalamus after ip injection with TNFα and IL-6
From: Increased hypothalamic serotonin turnover in inflammation-induced anorexia
Upstream regulators | |||||
|---|---|---|---|---|---|
| Â | TNF | IL-6 low | IL-6 high | TNFÂ +Â IL-6 low | TNFÂ +Â IL-6 high |
Cytokines | Â | Â | IFNG | IFNG | Â |
| Â | IFNG | IFNG | IL6 | IL6 | Â |
| Â | IL6 | IL6 | PRL | PRL | IFNG |
| Â | TGFB1 | PRL | TGFB1 | TGFB1 | TGFB1 |
Enzymes | Â | Â | TGFBR1 | TGFBR1 | Â |
| Â | Â | TGFBR1 | IKBKG | IKBKG | Â |
| Â | TGFBR1 | IKBKG | ALDH1A2 | ALDH1A2 | Â |
| Â | ALDH1A2 | PARP9 | PARP9 | PARP9 | TGFBR1 |
Transcription factors | Â | Â | SRF | Â | Â |
| Â | Â | Â | MKL1 | SRF | Â |
| Â | SRF | Â | SMAD7 | MKL1 | Â |
| Â | MKL1 | SMAD7 | CEBPB | CEBPB | SRF |
| Â | STAT1 | CEBPB | STAT1 | STAT1 | MKL1 |
| Â | IRF3 | IRF3 | IRF3 | IRF3 | SMAD7 |