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Table 1 Upstream regulators in hypothalamus after ip injection with TNFα and IL-6

From: Increased hypothalamic serotonin turnover in inflammation-induced anorexia

Upstream regulators
  TNF IL-6 low IL-6 high TNF + IL-6 low TNF + IL-6 high
Cytokines    IFNG IFNG  
  IFNG IFNG IL6 IL6  
  IL6 IL6 PRL PRL IFNG
  TGFB1 PRL TGFB1 TGFB1 TGFB1
Enzymes    TGFBR1 TGFBR1  
   TGFBR1 IKBKG IKBKG  
  TGFBR1 IKBKG ALDH1A2 ALDH1A2  
  ALDH1A2 PARP9 PARP9 PARP9 TGFBR1
Transcription factors    SRF   
    MKL1 SRF  
  SRF   SMAD7 MKL1  
  MKL1 SMAD7 CEBPB CEBPB SRF
  STAT1 CEBPB STAT1 STAT1 MKL1
  IRF3 IRF3 IRF3 IRF3 SMAD7