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Fig. 11 | BMC Neuroscience

Fig. 11

From: Empirical Bayesian significance measure of neuronal spike response

Fig. 11

Spike response function and EPSP possibly mediated by AMPA and NMDA receptors. a A mixture of fast and slow EPSPs, represented by two gamma distributions peaking at 5 and 50 ms, respectively. According to an electrophysiological study, rat CA1 pyramidal neurons showed sharp, strong and relatively slow EPSPs peaking at around 10 ms and lying over 10–100 ms, respectively [30], which were possibly mediated by AMPA and NMDA receptors. In the mixture, the amount of the slow EPSP was set as small as one third of the blue broken line. b The delayed response of the calcium indicator induced by the membrane voltage was represented by a convolution kernel, an alpha function of the delay time of 50 ms. c By convolving the convolution kernel b to the typical EPSP (membrane voltage), we have a typical response function obtained by our functional connectivity analysis. Contributions in the response function from AMPA- and NMDA-mediated EPSPs are displayed as blue lines

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