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Table 2 Results of the gPPI analyses in the contrast “successful shift > successful repeat”: left superior frontal gyrus and right superior frontal gyrus

From: Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients

Regions

BA

t value

Cluster size

Peak voxel coordinates (MNI)

X

Y

Z

Left superior frontal gyrus

      

 Positive coupling PD

      

  Ventral PCC

23

4.70

107

−9

−76

7

  

3.74

 

6

−76

10

  Right perirhinal cortex

36

3.85

20

24

−43

−11

 Positive coupling HC

      

  Precuneus

31

4.55

380

9

−55

25

  

4.30

 

−6

−49

28

  

4.22

 

−6

−61

22

  Right angular gyrus

39

4.45

62

51

−73

19

  Right frontal cortex

8

4.22

47

24

35

43

  Left frontal cortex

8

4.20

111

−21

29

43

  

4.08

 

−36

23

46

  

3.38

 

−9

47

43

  Right associative visual cortex

19

4.02

29

30

−88

16

  

3.80

 

24

−94

13

  Ventral PCC

23

3.95

29

3

−19

34

  Left angular gyrus

39

3.85

59

−45

−79

25

  

3.73

 

−51

−70

31

  

3.66

 

−51

−70

19

  Left DMPFC

9

3.78

17

−3

53

25

  PCC

30

3.69

16

−9

−58

7

 Negative coupling PD

      

  Left primary motor cortex

4

3.81

11

−15

−31

73

 Interaction effect positive coupling PD > HC (masked with main effect of positive coupling PD)

      

  Right perirhinal cortex

36

3.72

28

24

−43

−11

Right superior frontal gyrus

      

 Positive coupling HC

      

  Precuneus

31

5.00

484

6

−52

25

  

4.90

 

−3

−52

25

  

4.21

 

9

−55

13

  

3.63

16

3

−34

43

  Bilateral anterior prefrontal cortex

10

4.66

194

6

59

19

  

4.03

 

−6

56

28

  

3.85

 

9

47

4

  Left angular gyrus

39

4.34

149

−42

−79

28

  

4.03

 

−36

−64

25

  

3.96

 

−54

−61

16

  Right lingual gyrus

18

3.78

10

33

−88

1

  

3.44

 

24

−91

4

  Right angular gyrus

39

3.58

12

51

−73

19

 Negative coupling PD

      

  Right dACC

32

4.75

22

18

44

7

  Left primary motor cortex

4

4.04

28

−30

−25

52

  

3.86

 

−21

−25

52

 Interaction effect positive coupling: HC > PD (masked with main effect of positive coupling HC)

      

  Right dACC

32

4.34

43

15

44

7

 Interaction effect negative coupling: PD < HC (masked with main effect of negative coupling PD)

      

  Right dACC

32

4.41

56

18

44

7

  Left primary motor cortex

4

3.78

26

−27

−28

52

 Left parietal cortex

40

3.68

 

−33

−40

52

 Right parietal cortex

7

3.66

11

21

−58

46

  1. Results of the connectivity analyses: comparison of the PD and HC groups on the successful shift > successful repeat contrast. All areas were significant at an uncorrected threshold of p < .001, with an extent threshold of 10 voxels
  2. HC healthy controls, PD Parkinson’s disease, BA Brodmann area