Reduced task-related functional connectivity during a set-shifting task in unmedicated early-stage Parkinson’s disease patients

Table 1 Results of the gPPI analyses in the contrast “successful shift > successful repeat”: left DLPFC and right DLPFC

Regions	BA	t-value	Cluster size	Peak voxel coordinates (MNI)
Regions	BA	t-value	Cluster size	X	Y	Z
Left DLPFC
Positive coupling PD
Precuneus	7	4.19	66	3	−61	31
Right DMPFC	9	4.17	22	9	50	19
Positive coupling HC
PCC	23	4.82	361	−3	−55	22
Precuneus	31	4.58		−9	−58	31
PCC	23	4.43		9	−55	19
Left angular gyrus	39	4.36	126	−45	−73	22
Negative coupling PD
Left SFG	6	4.99	76	−9	−19	73
Right SFG	6	4.58	37	18	−19	70
Right primary somatosensory cortex	2	4.17	14	30	−37	70
Right SFG	6	3.72	26	12	−10	55
Interaction effect positive coupling: HC > PD (masked with main effect of positive coupling HC)
Right insular cortex	13	3.91	15	42	5	−11
Interaction effect negative coupling: PD < HC (masked with main effect of negative coupling PD)
Left SFG	6	4.50	57	−6	−22	70
		4.19		−15	−19	73
		3.89		−9	−7	73
Right SFG	6	3.70	13	51	−7	52
Right SFG	6	4.14	24	18	−19	70
Right primary Somatosensory cortex	1	4.14	15	30	−37	70
Right insular cortex	13	3.91	57	42	5	−11
Right DLPFC
Positive coupling PD
Right DMPFC	9	3.89	10	9	53	19
Positive coupling HC
PCC	31	4.47	197	−3	−61	22
	23	4.06		6	−58	19
	31	3.97		−3	−52	28
Left angular gyrus	39	4.01	137	−45	−76	25
		4.00		−36	−70	19
		3.76		−45	−61	16
Negative coupling PD
Left SFG	6	3.65	11	−18	−22	73

Results of the connectivity analyses: comparison of the PD and HC groups on the successful shift > successful repeat contrast. All areas were significant at an uncorrected threshold of p < .001, with an extent threshold of 10 voxels
HC healthy controls, PD Parkinson’s disease, BA Brodmann area

ISSN: 1471-2202