Fig. 4

The expression of cleaved caspase-3 and cytosolic cytochrome c. a Representative immunoblots of cleaved caspase-3 and cytosolic cytochrome c in the ipsilateral cortex from sham and injured mice. Optical densities were normalized to beta-actin. The ratio of the normalized data for the wild type/sham mice was given a value of one. Data from other groups are expressed as values relative to the value for the wild type/sham mice. There was a significant increase in cleaved caspase-3 (b) and cytosolic cytochrome c (c) protein levels in wild type TBI mice and a significant moderation of this effect the GCPII KO mice. Data were represented as mean ± SEM (n = 6 per group); *p < 0.05, versus sham control of the same genotype; ^# p < 0.05, versus injured WT mice