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Table 1 Confirmed hits from the NCC library screen

From: Development of a central nervous system axonal myelination assay for high throughput screening

Known mechanism of action Compound EC50 μM bavg
Kinase inhibitor Imatinib mesylate 1.4
Anti-cholinergic Atracurium Besylate 5.3
Mitotic inhibitors Docetaxel 0.1
  Methotrexate 0.1
  Tegafur 2.7
  Artesunate 3.3
Ion channels Zu-capsaicin 4.7
  Amiloride 8.9
  Oxcarbazepine 14.7
Na2+/K+ ATPase inhibitor Digoxin 11.3
γ-secretase inhibitors LY 411, 575a 0.00053
  BMS 708, 163a 0.067
  MRK 560a 0.082
  DAPTa 0.55
  1. aCompounds not part of the NCC library screen
  2. bN = ≥ 2