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Table 1 Confirmed hits from the NCC library screen

From: Development of a central nervous system axonal myelination assay for high throughput screening

Known mechanism of action

Compound

EC50 μM bavg

Kinase inhibitor

Imatinib mesylate

1.4

Anti-cholinergic

Atracurium Besylate

5.3

Mitotic inhibitors

Docetaxel

0.1

 

Methotrexate

0.1

 

Tegafur

2.7

 

Artesunate

3.3

Ion channels

Zu-capsaicin

4.7

 

Amiloride

8.9

 

Oxcarbazepine

14.7

Na2+/K+ ATPase inhibitor

Digoxin

11.3

γ-secretase inhibitors

LY 411, 575a

0.00053

 

BMS 708, 163a

0.067

 

MRK 560a

0.082

 

DAPTa

0.55

  1. aCompounds not part of the NCC library screen
  2. bN = ≥ 2
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BMC Neuroscience

ISSN: 1471-2202

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