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Fig. 7 | BMC Neuroscience

Fig. 7

From: Indomethacin treatment prior to pentylenetetrazole-induced seizures downregulates the expression of il1b and cox2 and decreases seizure-like behavior in zebrafish larvae

Fig. 7

Effect of indomethacin treatment prior to pentylenetetrazole-induced seizures on the number of seizure-like behaviors. Animals were exposed to 10, 100, or 307 μM indomethacin prior to pentylenetetrazole (PTZ)-induced seizures. Number of seizure-like behaviors was evaluated following visual observation during the 20 min of PTZ (15 mM) exposure. Seizure-like behavior was registered if the zebrafish larvae lost their body posture (stage 3). Data are presented as mean ± SEM (n = 6 per group). Statistical analysis was performed by one-way analysis of variance (ANOVA) with Bonferroni’s post hoc test. One asterisk (*) indicated that p ≤ 0.05; two asterisks (**) indicated that p ≤ 0.01; three asterisks (***) indicated that that p ≤ 0.001. SG seizure group

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BMC Neuroscience

ISSN: 1471-2202

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