Fig. 6

Effect of indomethacin treatment prior to pentylenetetrazole induced seizures on seizure latency. Animals were exposed to 10, 100, or 307 μM indomethacin for 24 h prior to pentylenetetrazole (PTZ)-induced seizures, and latency of the first seizure-like behavior (stage 3, equivalent to loss of body posture) was evaluated following visual observation. The seizure group (SG) was composed of animals that were exposed to 15 mM PTZ (n = 6 per group). Data are presented as mean ± SEM. Statistical analysis was performed by one-way analysis of variance (ANOVA) with Bonferroni’s post hoc test. One asterisk (*) indicated that p ≤ 0.05; two asterisks (**) indicated that p ≤ 0.01; three asterisks (***) indicated that that p ≤ 0.001