Fig. 3
From: Engraftment of enteric neural progenitor cells into the injured adult brain
Following concussion injury, ENSCs cluster around injured brain parenchyma, migrate to neurogenic niches, and induce focal neurogenesis. Concussion injury was induced over 5 days, ENSCs delivered systemically 3 days later, and brains analyzed after 10 weeks. Brain regions shown in each panel are indicated in (A). ENSCs are identified at the site of brain injury, both at the cortical surface (B, thin arrows) and in the parenchyma (B–G). ENSCs appear to be migrating from the injury site toward the ipsilateral dentate gyrus (B, thick arrows). Doublecortin + endogenous neurons are observed in increased numbers in the region of the transplanted cells in the dentate gyrus (E–G) and at the cortical surface (H, arrows highlight transplanted ENSCs adjacent to endogenous doublecortin + neurons)