Fig. 2

DARPP-32 neuronal loss in the left striatum after 90 nmol QA injection in PLP-α-syn and control mice. Overview of the unilaterally QA lesioned striatum in control (a) and PLP-α-syn mice (b) is demonstrated in representative sections at low magnification. In the non-lesioned side immunopositive neurons were easily detectable (arrows) at high magnification both in control (c) and PLP-α-syn mice (d). There was loss of DARPP-32 neurons, identifying only few preserved ones (arrow) or some degenerating cell profiles (arrowheads) on the lesioned side in controls (e) and PLP-α-syn mice (f). Statistical analysis with two-way ANOVA showed comparable neurodegeneration in control and PLP-α-syn mice (g). Data are presented as mean ± SEM. ***p < 0.001. L lesioned side, NL non-lesioned side