Table 2 Histological characteristics of the ST-ISODATA abnormal tissue signatures within the brains of the four macaques
MCAo | Signature | ||||
|---|---|---|---|---|---|
I | II | III | IV | V | |
Permanent | |||||
pMCAo1 | NA | Marked necrosis with dead neurons, tissue loss with gitter cells | Degenerate neurons, degenerate axons (spheroids) | Spongiosis, vacuolation, astrogliosis, vascular proliferation | NA |
pMCAo2 | NA | Marked necrosis with dead neurons, tissue loss with gitter cells | Degenerate neurons, degenerate axons (spheroids) | NA | NA |
3-h transient | |||||
tMCAo1 | Edema, spongiosis, astrocytosis, mineralization | NA | NA | Spongiosis, vacuolation, astrogliosis, vascular proliferation | Edema, necrosis, gitter cells |
tMCAo2 | NA | NA | NA | NA | Edema, necrosis, gitter cells |