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Table 2 Histological characteristics of the ST-ISODATA abnormal tissue signatures within the brains of the four macaques

From: Magnetic resonance imaging-based cerebral tissue classification reveals distinct spatiotemporal patterns of changes after stroke in non-human primates

MCAo Signature
I II III IV V
Permanent      
 pMCAo1 NA Marked necrosis with dead neurons, tissue loss with gitter cells Degenerate neurons, degenerate axons (spheroids) Spongiosis, vacuolation, astrogliosis, vascular proliferation NA
 pMCAo2 NA Marked necrosis with dead neurons, tissue loss with gitter cells Degenerate neurons, degenerate axons (spheroids) NA NA
3-h transient      
 tMCAo1 Edema, spongiosis, astrocytosis, mineralization NA NA Spongiosis, vacuolation, astrogliosis, vascular proliferation Edema, necrosis, gitter cells
 tMCAo2 NA NA NA NA Edema, necrosis, gitter cells
  1. NA not applicable