Fig. 7

Scutellarin enhanced NICD expression in astrocytes after MCAO. NICD expression is absent in astrocytes in the sham (A1–3). Its expression (red) was moderately induced after MCAO in GFAP positive astrocytes (green) at 7 days (B1–3) but was diminished at 14 days (D1–3). However, NICD expression was markedly increased in hypertrophic astrocytes in scutellarin treated MCAO rats (C1–3, E1–3) in comparison to the matching control groups (B1–3, D1–3). Scale bars: 50 µm. DAPI-blue