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Fig. 2 | BMC Neuroscience

Fig. 2

From: Novel transcripts reveal a complex structure of the human TRKA gene and imply the presence of multiple protein isoforms

Fig. 2

The human TRKA gene has numerous transcription start sites producing more alternative 5′ exons than mouse and rat TrkA genes. Results of the 5′ RACE analysis of TRKA mRNA of human (combined results of extracts from thalamus and SH-SY-5Y cell line), mouse (brain at embryonic day 13) and rat (PC12 cell line). Novel transcription start-sites are indicated in blue bold letters and marked with a blue arrow head. Transcription initiation sites deduced from GenBank sequences of previously described mRNAs and ESTs that are obtained with 5′ RACE analysis are displayed in bold underlined letters and designated with black asterisks with the corresponding GenBank accession numbers shown. Red and bold letters indicate alternative putative translation start sites with the conventional translation initiation site (producing TRKAII protein isoform) underlined. The translational start site from alternative reading frame that is used if exons 2…9 are spliced out in human tissues between exons 1 and 10 is indicated in pink bold letters. Exons are marked with grey background. The numbering is based on the human genome assembly GRCh38 (hg38), the mouse genome assembly GRCm38 (mm10) or the rat genome assembly RGSC6.0 (rn6)

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