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Fig. 1 | BMC Neuroscience

Fig. 1

From: Profilin 1 with the amyotrophic lateral sclerosis associated mutation T109M displays unaltered actin binding and does not affect the actin cytoskeleton

Fig. 1

PFN1 protein or mRNA levels are not affected by the PFN1 T109M mutation. a Measurement of relative PFN1 mRNA abundance by qRT-PCR of LCLs of five healthy controls and PFN1 T109M mutant LCLs of two ALS patients and three pre-clinical mutation carriers. Results were normalized to U6 snRNA using 2−ΔΔCt-method (bars indicate mean ± SEM). b Western blot comparing amounts of PFN1 protein of LCLs of five healthy controls, two PFN1 T109M mutant ALS patients and three pre-clinical carriers of the PFN1 T109M mutation. Same amounts of protein were pooled in the respective group. Actin is shown as a loading control

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BMC Neuroscience

ISSN: 1471-2202

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