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Fig. 7 | BMC Neuroscience

Fig. 7

From: Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors

Fig. 7

GABABRs control the incidence and the area of spfps-nmda more in DH than in VH. a Examples of CA1 stratum radiatum recordings from dorsal and ventral slices before and during application of the antagonist of GABABRs CGP 35348 (200 μM). One-minute long records (traces on the left) and single events (traces on the right) from each slice are shown. Note that although the rate of spfps-nmda was similarly accelerated by CGP 35348 in the dorsal and ventral slices, single events became larger only in the dorsal slice. b Cumulative data showing that blockade of GABABRs increased the incidence and area of spfps-nmda more in DH than in VH. The effect of CGP 35348 on the incidence is given as the difference in the percentage of slices displaying spfps-nmda before and after application of CGP 35348. Asterisks indicate statistically significant drug effects at p < 0.05 in each group (Wilcoxon test). Diesis indicates significant differences in the drug effect between DH and VH (Mann–Whitney U test, p < 0.05)

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