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Fig. 3 | BMC Neuroscience

Fig. 3

From: Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathways

Fig. 3

Aβ and mitochondrial dysfunction. Attachment of Aβ to inner membrane of mitochondria alters the different aspects of mitochondrial activity. Blocking electron chain through reducing complex IV activity, damaging mitochondrial DNA (mtDNA), inhibiting tricarboxylic acid (TCA) cycle and ATP production, enhancing cytochrome c release and activation of apoptotic pathways, and increasing the mitochondria production of ROS are some of the examples

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