Fig. 2From: Neuronal response in Alzheimer’s and Parkinson’s disease: the effect of toxic proteins on intracellular pathwaysAβ and GSK3. Aβ binding to membrane receptors such as insulin receptor (IR) inhibits the activity of Akt and wnt through PI3K inhibition. Inactivation of Akt and wnt consequently dephosphorylate GSK3 which causes tau hyper-phosphorylation and microtubular disorganisationBack to article page