Fig. 1

The PGC mammalian family and the Drosophila melanogaster protein SRL share conserved protein domains. a Aligned sequences show the position of each domain in one D. melanogaster and three human PGC family protein sequences. Light upward diagonal indicates proline rich region, wide downward diagonal indicates serine rich region, dark vertical indicates RNA recognition region, solid black box indicates nuclear localization sequence, black frame indicates arginine rich region, LXXLL and FEALLL indicate leucine rich nuclear recognition motifs. b A multiple alignment between PGC-1α, PGC-1β, PRC and SRL shows a high degree of sequence conservation within the RNA recognition motif found at the carboxyl terminus of each protein. Domains were identified using ScanProsite [41], alignment was done using ClustalW2 [42]. Protein sequences obtained from UniProt, accession numbers [Uniprot NP_037393 (PGC-1α)], [Uniprot NP_573570 (PGC-1β)], [Uniprot NP_055877 (PRC)] and [Uniprot NP_730835 (SRL)]. Elements of this figure were adapted from Scarpulla et al. [43]