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Fig. 1 | BMC Neuroscience

Fig. 1

From: Absence of M-Ras modulates social behavior in mice

Fig. 1

Altered social behavior in Mras / (KO) males. a Cumulative duration of aggressive behavior by the resident was scored during 10-min resident-intruder tests. Mras / (KO) residents displayed enhanced aggressive behavior towards KO and WTsw intruders but not towards WT or oB6 intruders (‘oB6’: males that were on the C57BL/6 J background but that either had one knockout mutation or that expressed one transgene). WT/WT (res./intr.) vs. KO/KO, p = 0.0325; KO/KO vs. KO/WT, p = 0.0325; KO/KO vs. KO/oB6, p = 0.0441; KO/WT vs. KO/WTsw, p = 0.0325; KO/oB6 vs. KO/WTsw, p = 0.0441; all others not significant. b Social investigations (sniffing) by the residents during the first 5 min of the resident-intruder tests were scored. WT/WT (res./intr.) vs. KO/KO, p < 0.0001; KO/KO vs. KO/oB6, p = 0.0185. c Social investigations by the intruders during the first five min. of the resident-intruder tests were scored. There were no significant differences for both WT and KO intruders. d Digging behavior by the residents was scored during the first 5 min of the resident-intruder tests. p = 0.0001 for WT/WT vs. KO/KO. e Digging behavior by the intruders was scored during the first 5 min of the resident-intruder tests. There were no significant differences for both WT and KO intruders. be Error bars represent SEM. f ‘Corner’ behavior was scored for residents, showing more frequent anxiety-related behavior of Mras / (KO) males. p < 0.0001 for all WT residents vs. all KO residents combined; not significant between individual groups. af n = 10 for all groups except oB6, where n = 7. g Open Field tests: The amount of time mice spent at the center of an open and brightly lit white box was scored over a period of ten min. Error bars represent SEM, n = 10 for all groups except n = 11 for Mras / males; p = 0.0225; females, p = 0.0134. h Mating assays: Male mating behavior was scored in 10-min. interactions between combinations of WT and KO males and females. n = 10 for all groups; p = 0.0007 for WT/WT (male/female) vs. KO/KO; p = 0.0108 for KO/WT vs. KO/KO; not significant for WT/WT vs. WT/KO

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