TY - JOUR AU - Elphick, M. R. AU - Mirabeau, O. PY - 2014 DA - 2014// TI - The evolution and variety of RFamide-type neuropeptides: insights from deuterostomian invertebrates JO - Front Endocrinol Lausanne VL - 5 ID - Elphick2014 ER - TY - JOUR AU - Baldwin, G. S. AU - Patel, O. AU - Shulkes, A. PY - 2010 DA - 2010// TI - Evolution of gastrointestinal hormones: the cholecystokinin/gastrin family JO - Curr Opin Endocrinol Diabetes Obes VL - 17 ID - Baldwin2010 ER - TY - JOUR AU - Hewes, R. S. AU - Taghert, P. H. PY - 2001 DA - 2001// TI - Neuropeptides and neuropeptide receptors in the Drosophila melanogaster genome JO - Genome Res VL - 11 UR - https://doi.org/10.1101/gr.169901 DO - 10.1101/gr.169901 ID - Hewes2001 ER - TY - JOUR AU - Chufán, E. E. AU - De, M. AU - Eipper, B. A. AU - Mains, R. E. AU - Amzel, L. M. PY - 2009 DA - 2009// TI - Amidation of bioactive peptides: the structure of the lyase domain of the amidating enzyme JO - Structure VL - 17 UR - https://doi.org/10.1016/j.str.2009.05.008 DO - 10.1016/j.str.2009.05.008 ID - Chufán2009 ER - TY - JOUR AU - Bousquet-Moore, D. AU - Mains, R. E. PY - 2010 DA - 2010// TI - Eipper BA Peptidylgycine α-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function JO - J Neurosci Res VL - 88 UR - https://doi.org/10.1002/jnr.22404 DO - 10.1002/jnr.22404 ID - Bousquet-Moore2010 ER - TY - JOUR AU - Rajagopal, C. AU - Stone, K. L. AU - Mains, R. E. AU - Eipper, B. A. PY - 2010 DA - 2010// TI - Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme JO - J Biol Chem VL - 285 UR - https://doi.org/10.1074/jbc.M110.145334 DO - 10.1074/jbc.M110.145334 ID - Rajagopal2010 ER - TY - JOUR AU - Prigge, S. T. AU - Mains, R. E. AU - Eipper, B. A. AU - Amzel, L. M. PY - 2000 DA - 2000// TI - New insights into copper mono-oxygenases and peptide amidation: structure, mechanism and function JO - Cell Mol Life Sci VL - 57 UR - https://doi.org/10.1007/PL00000763 DO - 10.1007/PL00000763 ID - Prigge2000 ER - TY - JOUR AU - Eipper, B. A. AU - Milgranas, L. AU - Husten, E. J. AU - Yun, H. Y. AU - Mains, R. E. PY - 1993 DA - 1993// TI - Peptidylglycine alpha-amidating monooxygenase: a multifunctional protein with catalytic, processing, and routing domains JO - Protein Sci VL - 2 UR - https://doi.org/10.1002/pro.5560020401 DO - 10.1002/pro.5560020401 ID - Eipper1993 ER - TY - JOUR AU - Kolhekar, A. S. AU - Bell, J. AU - Shiozaki, E. N. AU - Jin, L. AU - Keutmann, H. T. AU - Hand, T. A. AU - Mains, R. E. AU - Eipper, B. A. PY - 2002 DA - 2002// TI - Essential features of the catalytic core of peptidyl-alpha-hydroxyglycine alpha-amidating lyase JO - Biochemistry VL - 41 UR - https://doi.org/10.1021/bi0260280 DO - 10.1021/bi0260280 ID - Kolhekar2002 ER - TY - JOUR AU - Merkler, D. J. AU - Kulathila, R. AU - Consalvo, A. P. AU - Young, S. D. PY - 1992 DA - 1992// TI - Ash DE.18O isotopic 13C NMR shift as proof that bifunctional peptidylglycine alpha-amidating enzyme is a monooxygenase JO - Biochemistry VL - 31 UR - https://doi.org/10.1021/bi00147a011 DO - 10.1021/bi00147a011 ID - Merkler1992 ER - TY - JOUR AU - Chen, P. AU - Solomon, E. PY - 2004 DA - 2004// TI - Oxygen activation by the noncoupled binuclear copper site in peptidylglycine alpha-hydroxylating monooxygenase. Reaction mechanism and role of the noncoupled nature of the active site JO - J Am Chem Soc VL - 126 UR - https://doi.org/10.1021/ja031564g DO - 10.1021/ja031564g ID - Chen2004 ER - TY - JOUR AU - Czyzyk, T. A. AU - Ning, Y. AU - Hsu, M. S. AU - Peng, B. AU - Mains, R. E. AU - Eipper, B. A. AU - Pintar, J. E. PY - 2005 DA - 2005// TI - Deletion of peptide amidation enzymatic activity leads to edema and embryonic lethality in the mouse JO - Dev Biol VL - 287 UR - https://doi.org/10.1016/j.ydbio.2005.09.001 DO - 10.1016/j.ydbio.2005.09.001 ID - Czyzyk2005 ER - TY - JOUR AU - Lénárd, L. AU - Kovács, A. AU - Ollmann, T. AU - Péczely, L. AU - Zagoracz, O. AU - Gálosi, R. AU - László, K. PY - 2014 DA - 2014// TI - Positive reinforcing effects of RFamide-related peptide-1 in the rat central nucleus of amygdala JO - Behav Brain Res VL - 275 UR - https://doi.org/10.1016/j.bbr.2014.08.051 DO - 10.1016/j.bbr.2014.08.051 ID - Lénárd2014 ER - TY - JOUR AU - Sharma, S. D. AU - Raghuraman, G. AU - Lee, M. S. AU - Prabhakar, N. R. AU - Kumar, G. K. PY - 2009 DA - 2009// TI - Intermittent hypoxia activates peptidylglycine alpha-amidating monooxygenase in rat brain stem via reactive oxygen species-mediated proteolytic processing JO - J Appl Physiol VL - 106 UR - https://doi.org/10.1152/japplphysiol.90702.2008 DO - 10.1152/japplphysiol.90702.2008 ID - Sharma2009 ER - TY - JOUR AU - Merkler, D. J. PY - 1994 DA - 1994// TI - C-terminal amidated peptides: production by the in vitro enzymatic amidation of glycine-extended peptides and the importance of the amide to bioactivity JO - Enzym Microb Technol VL - 16 UR - https://doi.org/10.1016/0141-0229(94)90014-0 DO - 10.1016/0141-0229(94)90014-0 ID - Merkler1994 ER - TY - JOUR AU - Tsutsui, K. AU - Ukena, K. PY - 2006 DA - 2006// TI - Hypothalamic LPXRF-amide peptides in vertebrates: identification, localization and hypophysiotropic activity JO - Peptides VL - 25 UR - https://doi.org/10.1016/j.peptides.2005.06.036 DO - 10.1016/j.peptides.2005.06.036 ID - Tsutsui2006 ER - TY - JOUR AU - Seizinger, B. R. AU - Liebisch, D. C. AU - Gramsch, C. AU - Herz, A. AU - Weber, E. AU - Evans, C. J. AU - Esch, F. S. AU - Böhlen, P. PY - 1985 DA - 1985// TI - Isolation and structure of a novel C-terminally amidated opioid peptide, amidorphin, from bovine adrenal medulla JO - Nature VL - 313 UR - https://doi.org/10.1038/313057a0 DO - 10.1038/313057a0 ID - Seizinger1985 ER - TY - JOUR AU - Jensen, T. D. AU - Holst, J. J. AU - Fahrenkrug, J. PY - 1994 DA - 1994// TI - Secretion of pancreastatins from the porcine digestive tract JO - Scand J Gastroenterol VL - 29 UR - https://doi.org/10.3109/00365529409094853 DO - 10.3109/00365529409094853 ID - Jensen1994 ER - TY - JOUR AU - Lovejoy, D. A. AU - Balment, R. J. PY - 1999 DA - 1999// TI - Evolution and physiology of the corticotropin-releasing factor (CRF) family of neuropeptides in vertebrates JO - Gen Comp Endocrinol VL - 115 UR - https://doi.org/10.1006/gcen.1999.7298 DO - 10.1006/gcen.1999.7298 ID - Lovejoy1999 ER - TY - JOUR AU - Vinson, G. P. AU - Whitehouse, B. J. AU - Dell, A. AU - Etienne, T. AU - Morris, H. R. PY - 1980 DA - 1980// TI - Characterisation of an adrenal zona glomerulosa-stimulating component of posterior pituitary extracts as alpha-MSH JO - Nature VL - 284 UR - https://doi.org/10.1038/284464a0 DO - 10.1038/284464a0 ID - Vinson1980 ER - TY - JOUR AU - Weber, E. AU - Esch, F. S. AU - Böhlen, P. AU - Paterson, S. AU - Corbett, A. D. AU - McKnight, A. T. AU - Kosterlitz, H. W. AU - Barchas, J. D. AU - Evans, C. J. PY - 1983 DA - 1983// TI - Metorphamide: isolation, structure, and biologic activity of an amidated opioid octapeptide from bovine brain JO - Proc Natl Acad Sci USA VL - 80 UR - https://doi.org/10.1073/pnas.80.23.7362 DO - 10.1073/pnas.80.23.7362 ID - Weber1983 ER - TY - JOUR AU - Nilsson, A. AU - Carlquist, M. AU - Jörnvall, H. AU - Mutt, V. PY - 1980 DA - 1980// TI - Isolation and characterization of chicken secretin JO - Eur J Biochem VL - 112 UR - https://doi.org/10.1111/j.1432-1033.1980.tb07216.x DO - 10.1111/j.1432-1033.1980.tb07216.x ID - Nilsson1980 ER - TY - JOUR AU - Lederis, K. AU - Letter, A. AU - McMaster, D. AU - Moore, G. AU - Schlesinger, D. PY - 1982 DA - 1982// TI - Complete amino acid sequence of urotensin I, a hypotensive and corticotropin-releasing neuropeptide from Catostomus JO - Science VL - 218 UR - https://doi.org/10.1126/science.6981844 DO - 10.1126/science.6981844 ID - Lederis1982 ER - TY - JOUR AU - Furukawa, Y. AU - Nakamaru, K. AU - Wakayama, H. AU - Fujisawa, Y. AU - Minakata, H. AU - Ohta, S. AU - Morishita, F. AU - Matsushima, O. AU - Li, L. AU - Romanova, E. AU - Sweedler, J. V. AU - Park, J. H. AU - Romero, A. AU - Cropper, E. C. AU - Dembrow, N. C. AU - Jing, J. AU - Weiss, K. R. AU - Vilim, F. S. PY - 2001 DA - 2001// TI - The enterins: a novel family of neuropeptides isolated from the enteric nervous system and CNS of Aplysia JO - J Neurosci VL - 21 ID - Furukawa2001 ER - TY - JOUR AU - Sandberg, M. AU - Weber, S. G. PY - 2003 DA - 2003// TI - Techniques for neuropeptide determination JO - Trends Analyt Chem VL - 22 UR - https://doi.org/10.1016/S0165-9936(03)00910-5 DO - 10.1016/S0165-9936(03)00910-5 ID - Sandberg2003 ER - TY - JOUR AU - Grant, G. A. AU - Crankshaw, M. W. AU - Gorka, J. PY - 1997 DA - 1997// TI - Edman sequencing as tool for characterization of synthetic peptides JO - Methods Enzymol VL - 289 UR - https://doi.org/10.1016/S0076-6879(97)89056-8 DO - 10.1016/S0076-6879(97)89056-8 ID - Grant1997 ER - TY - CHAP AU - Glick, R. B. AU - Pasternak, J. J. ED - Glick, R. B. ED - Pasternak, J. J. PY - 1998 DA - 1998// TI - Recombinant DNA technology BT - Molecular biotechnology: principles and applications of recombinant DNA PB - ASM Press CY - Washington ID - Glick1998 ER - TY - JOUR AU - Zhu, P. AU - Bowden, P. AU - Zhang, D. AU - Marshall, J. G. PY - 2011 DA - 2011// TI - Mass spectrometry of peptides and proteins from human blood JO - Mass Spectrom Rev VL - 30 ID - Zhu2011 ER - TY - STD TI - Goding JW. Monoclonal antibodies: principles and practice. In: Goding JW, editor. Production and application of monoclonal antobodies in cellbiology, biochemistry and immunology. 3rd ed. London: Academic Press; 1996. p. 141–180. ID - ref29 ER - TY - JOUR AU - Kim, K. H. AU - Shim, J. H. AU - Seo, E. H. AU - Cho, M. C. AU - Kang, J. W. AU - Kim, S. H. AU - Yu, D. Y. AU - Song, E. Y. AU - Lee, H. G. AU - Sohn, J. H. AU - Kim, J. AU - Dinarello, C. A. AU - Yoon, D. Y. PY - 2008 DA - 2008// TI - Interleukin-32 monoclonal antibodies for immunohistochemistry, Western blotting, and ELISA JO - J Immunol Methods VL - 333 UR - https://doi.org/10.1016/j.jim.2007.12.017 DO - 10.1016/j.jim.2007.12.017 ID - Kim2008 ER - TY - JOUR AU - Iwabata, H. AU - Yoshida, M. AU - Komatsu, Y. PY - 2005 DA - 2005// TI - Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies JO - Proteomics VL - 5 UR - https://doi.org/10.1002/pmic.200500042 DO - 10.1002/pmic.200500042 ID - Iwabata2005 ER - TY - JOUR AU - Jacobowitz, D. M. AU - O’Donohue, T. L. PY - 1978 DA - 1978// TI - alpha-melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain JO - Proc Natl Acad Sci USA VL - 75 UR - https://doi.org/10.1073/pnas.75.12.6300 DO - 10.1073/pnas.75.12.6300 ID - Jacobowitz1978 ER - TY - JOUR AU - Oliver, C. AU - Porter, J. C. PY - 1978 DA - 1978// TI - Distribution and characterization of alpha-melanocyte-stimulating hormone in the rat brain JO - Endocrinology VL - 102 UR - https://doi.org/10.1210/endo-102-3-697 DO - 10.1210/endo-102-3-697 ID - Oliver1978 ER - TY - JOUR AU - Sonders, M. AU - Brachas, J. D. AU - Weber, E. PY - 1984 DA - 1984// TI - Regional distribution of metorphamide in rat and guinea pig brain JO - Biochem Biophys Res Commun VL - 122 UR - https://doi.org/10.1016/0006-291X(84)91174-4 DO - 10.1016/0006-291X(84)91174-4 ID - Sonders1984 ER - TY - JOUR AU - O’Donohue, T. L. AU - Charlton, C. G. AU - Miller, R. L. AU - Boden, G. AU - Jacobowitz, D. M. PY - 1981 DA - 1981// TI - Identification, characterization, and distribution of secretin immunoreactivity in rat and pig brain JO - Proc Natl Acad Sci USA VL - 78 UR - https://doi.org/10.1073/pnas.78.8.5221 DO - 10.1073/pnas.78.8.5221 ID - O’Donohue1981 ER - TY - JOUR AU - Kozicz, T. AU - Yanaihara, H. AU - Arimura, A. PY - 1998 DA - 1998// TI - Distribution of urocortin-like immunoreactivity in the central nervous system of the rat JO - J Comp Neurol VL - 391 UR - https://doi.org/3.0.CO;2-6 DO - 3.0.CO;2-6 ID - Kozicz1998 ER - TY - JOUR AU - Solcia, E. AU - Usellini, L. AU - Buffa, R. AU - Rindi, G. AU - Villani, L. AU - Zampatti, C. AU - Silini, E. PY - 1987 DA - 1987// TI - Endocrine cells producing regulatory peptides JO - Experientia VL - 43 UR - https://doi.org/10.1007/BF01945362 DO - 10.1007/BF01945362 ID - Solcia1987 ER - TY - JOUR AU - Luger, T. A. AU - Scholzen, T. E. AU - Brzoska, T. AU - Böhm, M. PY - 2003 DA - 2003// TI - New insights into the functions of alpha-MSH and related peptides in the immune system JO - Ann N Y Acad Sci VL - 994 UR - https://doi.org/10.1111/j.1749-6632.2003.tb03172.x DO - 10.1111/j.1749-6632.2003.tb03172.x ID - Luger2003 ER - TY - STD TI - Harlow E, Lane D. Using antibodies: a laboratory manual. In: Harlow ED, Lane D editors. New York: Cold Spring Harbor Laboratory Press; 1996. p. 222–66. ID - ref39 ER - TY - JOUR AU - Ohnishi, S. AU - Kamikubo, H. AU - Onitsuka, M. AU - Kataoka, M. AU - Shortle, D. PY - 2006 DA - 2006// TI - Conformational preference of polyglycine in solution to elongated structure JO - J Am Chem Soc VL - 128 UR - https://doi.org/10.1021/ja066008b DO - 10.1021/ja066008b ID - Ohnishi2006 ER - TY - CHAP AU - Hockfield, S. AU - Carlson, S. AU - Evans, C. AU - Levitt, P. AU - Pintar, J. AU - Silberstein, L. ED - Hockfield, S. ED - Carlson, S. ED - Evans, C. ED - Levitt, P. ED - Pintar, J. ED - Silberstein, L. PY - 1993 DA - 1993// TI - Selected methods for antibody and nucleic acid probes BT - Molecular probes of the nervous system PB - Cold Spring Harbor Laboratory Press CY - New York ID - Hockfield1993 ER - TY - JOUR AU - StGroth, S. F. AU - Scheidegger, D. PY - 1980 DA - 1980// TI - Production of monoclonal antibodies: strategy and tactics JO - J Immunol Methods VL - 35 UR - https://doi.org/10.1016/0022-1759(80)90146-5 DO - 10.1016/0022-1759(80)90146-5 ID - StGroth1980 ER - TY - JOUR AU - Loi, P. K. AU - McGraw, H. F. AU - Tublitz, N. J. PY - 1997 DA - 1997// TI - Peptide detection in single cells using a dot immunoblot assay JO - Peptides VL - 18 UR - https://doi.org/10.1016/S0196-9781(97)00006-5 DO - 10.1016/S0196-9781(97)00006-5 ID - Loi1997 ER - TY - JOUR AU - Asai, M. AU - Zubieta, M. AU - Matamoros-Trejo, G. AU - Linares, G. AU - Agustin, P. PY - 1998 DA - 1998// TI - Diurnal variations of opioid peptides and synenkephalin in vitro release in the amygdala of kindled rats JO - Neuropeptides VL - 32 UR - https://doi.org/10.1016/S0143-4179(98)90051-8 DO - 10.1016/S0143-4179(98)90051-8 ID - Asai1998 ER - TY - JOUR AU - Anton, B. AU - Fein, J. AU - To, T. AU - Li, X. AU - Silberstein, L. AU - Evans, C. J. PY - 1996 DA - 1996// TI - Immunohistochemical localization of ORL-1 in the central nervous system of the rat JO - J Comp Neurol VL - 368 UR - https://doi.org/3.0.CO;2-5 DO - 3.0.CO;2-5 ID - Anton1996 ER - TY - BOOK AU - Paxinos, G. AU - Watson, C. PY - 1998 DA - 1998// TI - The rat brain in stereotaxic coordinates PB - New York Academic Press CY - New York ID - Paxinos1998 ER - TY - JOUR AU - Bicknell, A. B. PY - 2008 DA - 2008// TI - The tissue-specific processing of pro-opiomelanocortin JO - J Neuroendocrinol VL - 20 UR - https://doi.org/10.1111/j.1365-2826.2008.01709.x DO - 10.1111/j.1365-2826.2008.01709.x ID - Bicknell2008 ER - TY - JOUR AU - Boarder, M. R. AU - Contractor, H. AU - Marriott, D. AU - McArdle, W. PY - 1985 DA - 1985// TI - Metorphamide, a C-terminally amidated opioid peptide, in human adrenal and human phaeochromocytoma JO - Regul Pept VL - 12 UR - https://doi.org/10.1016/0167-0115(85)90184-3 DO - 10.1016/0167-0115(85)90184-3 ID - Boarder1985 ER - TY - JOUR AU - Fekete, E. M. AU - Zorrilla, E. P. PY - 2007 DA - 2007// TI - Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs JO - Front Neuroendocrinol VL - 28 UR - https://doi.org/10.1016/j.yfrne.2006.09.002 DO - 10.1016/j.yfrne.2006.09.002 ID - Fekete2007 ER - TY - JOUR AU - Shioda, S. AU - Ohtaki, H. AU - Nakamachi, T. AU - Dohi, K. AU - Watanabe, J. AU - Nakajo, S. AU - Arata, S. AU - Kitamura, S. AU - Okuda, H. AU - Takenoya, F. AU - Kitamura, Y. PY - 2006 DA - 2006// TI - Pleiotropic functions of PACAP in the CNS: neuroprotection and neurodevelopment JO - Ann N Y Acad Sci VL - 1070 UR - https://doi.org/10.1196/annals.1317.080 DO - 10.1196/annals.1317.080 ID - Shioda2006 ER - TY - JOUR AU - Higashijima, T. AU - Uzu, S. AU - Nakajima, T. AU - Ross, E. M. PY - 1988 DA - 1988// TI - Mastoparan, a peptide toxin from wasp venom, mimics receptors by activating GTP-binding regulatory proteins (G proteins) JO - J Biol Chem VL - 263 ID - Higashijima1988 ER - TY - JOUR AU - Tezapsidis, N. AU - Parish, D. C. PY - 1994 DA - 1994// TI - Characterization of a metalloprotease from ovine chromaffin granules, which cleaves a proenkephalin fragment (BAM12P) at a single arginine residue JO - Biochem J VL - 301 UR - https://doi.org/10.1042/bj3010607 DO - 10.1042/bj3010607 ID - Tezapsidis1994 ER - TY - JOUR AU - Catania, A. PY - 2008 DA - 2008// TI - Neuroprotective actions of melanocortins: a therapeutic opportunity JO - Trends Neurosci VL - 31 UR - https://doi.org/10.1016/j.tins.2008.04.002 DO - 10.1016/j.tins.2008.04.002 ID - Catania2008 ER - TY - JOUR AU - Brzoska, T. AU - Böhm, M. AU - Lügering, A. AU - Loser, K. AU - Luger, T. A. PY - 2010 DA - 2010// TI - Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore JO - Adv Exp Med Biol VL - 681 UR - https://doi.org/10.1007/978-1-4419-6354-3_8 DO - 10.1007/978-1-4419-6354-3_8 ID - Brzoska2010 ER - TY - JOUR AU - Vaudry, D. AU - Falluel-Morel, A. AU - Bourgault, S. AU - Basille, M. AU - Burel, D. AU - Wurtz, O. AU - Fournier, A. AU - Chow, B. K. AU - Hashimoto, H. AU - Galas, L. AU - Vaudry, H. PY - 2009 DA - 2009// TI - Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery JO - Pharmacol Rev VL - 61 UR - https://doi.org/10.1124/pr.109.001370 DO - 10.1124/pr.109.001370 ID - Vaudry2009 ER - TY - JOUR AU - Rehfeld, J. F. AU - Bundgaard, J. R. AU - Goetze, J. P. AU - Friis-Hansen, L. AU - Hilsted, L. AU - Johnsen, A. H. PY - 2004 DA - 2004// TI - Naming progastrin-derived peptides JO - Regul Pept VL - 120 UR - https://doi.org/10.1016/j.regpep.2004.03.006 DO - 10.1016/j.regpep.2004.03.006 ID - Rehfeld2004 ER - TY - JOUR AU - D’Agostino, G. AU - Diano, S. PY - 2010 DA - 2010// TI - Alpha-melanocyte stimulating hormone: production and degradation JO - J Mol Med Berl VL - 88 UR - https://doi.org/10.1007/s00109-010-0651-0 DO - 10.1007/s00109-010-0651-0 ID - D’Agostino2010 ER - TY - JOUR AU - Loh, Y. P. AU - Kim, T. AU - Rodriguez, Y. M. AU - Cawley, N. X. PY - 2004 DA - 2004// TI - Secretory granule biogenesis and neuropeptide sorting to the regulated secretory pathway in neuroendocrine cells JO - J Mol Neurosci VL - 22 UR - https://doi.org/10.1385/JMN:22:1-2:63 DO - 10.1385/JMN:22:1-2:63 ID - Loh2004 ER -