Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Table 5 Tier C variables significantly correlated with any miRNA in AUD subjects (FDR < 0.05)

miRNA	Variable	AUD				Ctrl				All
miRNA	Variable	R	P-value	BH FDR	N	R	P-value	BH FDR	N	R	P-value	BH FDR
In all miRNAs
let-7a-5p	Heavy drinking days last week	0.846	3.1E−06	0.034	9
mir-93	Heavy drinking days last week	0.869	1.3E−07	0.006	10
miR-139-5p	Heavy drinking days last week	0.992	2.2E−06	0.048	4
miR-1180-3p	Heavy drinking days last week	0.975	5.07E−06	0.043	3
miR-584-5p	Left lateral fusiform gyrus	0.804	4.03E−06	0.040	17	−0.524	0.264	1	10	0.421	0.011	0.541
miR-16-2-3p	Left precuneus	0.977	4.38E−06	0.040	8	−0.045	0.925	0.995	7	0.540	0.013	0.577
mir-5010	Left subparietal sulcus	0.934	4.22E−07	0.014	12	0.729	0.026	0.988	7	0.807	7.80E−07	0.038
miR-4433-3p	Right insular white matter	0.948	2.59E−06	0.047	10	0.004	0.992	1	8	0.309	0.157	1
miR-4433b-5p	Right insular white matter	0.948	2.59E−06	0.047	10	0.004	0.992	1	8	0.309	0.157	1
mir-378a	Right medial orbital olfactory sulcus	0.821	1.85E−06	0.046	17	−0.268	0.520	1	10	0.463	0.004	0.597
miR-150-3p	Right paracentral white matter	0.830	2.78E−06	0.034	16	0.724	0.015	0.616	8	0.702	4.61E−06	0.062
miR-192-5p	Right rostral anterior cingulate	0.813	2.74E−06	0.038	17	−0.123	0.751	0.993	10	0.469	0.004	0.356
mir-664	Systolic blood pressure	0.995	3.18E−08	0.003	8	−0.179	0.838	1	4	0.934	4.52E−07	0.044

Pearson correlation analysis of miRNA expression levels in AUD subjects reveal significant relationships between specific miRNA expression levels and other medical, drinking and neuroimaging variables that were significantly different in AUD subjects
R Pearson correlation coefficient, P-value uncorrected P value for correlation, BH FDR Benjamini-Hochberg False Discovery Rate corrected P value, N number of pairs used in the calculation

ISSN: 1471-2202