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Table 5 Tier C variables significantly correlated with any miRNA in AUD subjects (FDR < 0.05)

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

miRNA Variable AUD Ctrl All
R P-value BH FDR N R P-value BH FDR N R P-value BH FDR
In all miRNAs
 let-7a-5p Heavy drinking days last week 0.846 3.1E−06 0.034 9        
 mir-93 Heavy drinking days last week 0.869 1.3E−07 0.006 10        
 miR-139-5p Heavy drinking days last week 0.992 2.2E−06 0.048 4        
 miR-1180-3p Heavy drinking days last week 0.975 5.07E−06 0.043 3        
 miR-584-5p Left lateral fusiform gyrus 0.804 4.03E−06 0.040 17 −0.524 0.264 1 10 0.421 0.011 0.541
 miR-16-2-3p Left precuneus 0.977 4.38E−06 0.040 8 −0.045 0.925 0.995 7 0.540 0.013 0.577
 mir-5010 Left subparietal sulcus 0.934 4.22E−07 0.014 12 0.729 0.026 0.988 7 0.807 7.80E−07 0.038
 miR-4433-3p Right insular white matter 0.948 2.59E−06 0.047 10 0.004 0.992 1 8 0.309 0.157 1
 miR-4433b-5p Right insular white matter 0.948 2.59E−06 0.047 10 0.004 0.992 1 8 0.309 0.157 1
 mir-378a Right medial orbital olfactory sulcus 0.821 1.85E−06 0.046 17 −0.268 0.520 1 10 0.463 0.004 0.597
 miR-150-3p Right paracentral white matter 0.830 2.78E−06 0.034 16 0.724 0.015 0.616 8 0.702 4.61E−06 0.062
 miR-192-5p Right rostral anterior cingulate 0.813 2.74E−06 0.038 17 −0.123 0.751 0.993 10 0.469 0.004 0.356
 mir-664 Systolic blood pressure 0.995 3.18E−08 0.003 8 −0.179 0.838 1 4 0.934 4.52E−07 0.044
  1. Pearson correlation analysis of miRNA expression levels in AUD subjects reveal significant relationships between specific miRNA expression levels and other medical, drinking and neuroimaging variables that were significantly different in AUD subjects
  2. R Pearson correlation coefficient, P-value uncorrected P value for correlation, BH FDR Benjamini-Hochberg False Discovery Rate corrected P value, N number of pairs used in the calculation