Table 3 Most consistently changed miRNAs in AUD
Symbol | RNA-seq | Microarray | |||||||
|---|---|---|---|---|---|---|---|---|---|
miRBase acc# | miRBase family | MiRBase fam acc # | Ctrl RPM | AUD RPM | % Δ AUD | P-value | % Δ AUD | P-value | |
Tier A: RNA-seq p < 0.05, Array p < 0.1, consistent % Δ AUD | |||||||||
 mir-96 | MI0000098 | mir-96 | MIPF0000072 | 4.6 | 11.3 | 142.6 | 0.031 | 15.0 | 0.059 |
 mir-320b-1 | MI0003776 | mir-320 | MIPF0000163 | 61.0 | 144.6 | 137.1 | 0.004 | 22.2 | 0.071 |
 mir-1976 | MI0009986 | mir-1976 | MIPF0001633 | 4.1 | 9.9 | 138.1 | 0.039 | 24.1 | 0.081 |
Tier B: RNA-seq p < 0.05, consistent % Δ AUD | |||||||||
 mir-24-1 | MI0000080 | mir-24 | MIPF0000041 | 31.3 | 90.5 | 189.4 | 0.008 | 6.2 | 0.338 |
 mir-30a | MI0000088 | mir-30 | MIPF0000005 | 108.2 | 209.9 | 94.0 | 0.014 | 5.1 | 0.860 |
 mir-92b | MI0003560 | mir-25 | MIPF0000013 | 7141.9 | 4553.8 | −36.2 | 0.016 | −8.2 | 0.312 |
 miR-96-5p | MIMAT0000095 | mir-96 | MIPF0000072 | 111.7 | 252.0 | 125.5 | 0.018 | 8.0 | 0.455 |
 mir-127 | MI0000472 | mir-127 | MIPF0000080 | 68.6 | 158.9 | 131.5 | 0.021 | 8.4 | 0.455 |
 mir-136 | MI0000475 | mir-136 | MIPF0000099 | 4.4 | 9.7 | 121.2 | 0.035 | 1.5 | 0.760 |
 miR-301a-3p | MIMAT0000688 | mir-130 | MIPF0000034 | 205.9 | 85.1 | −58.7 | 0.045 | −2.4 | 0.878 |
 mir-320b-2 | MI0003839 | mir-320 | MIPF0000163 | 61.3 | 148.8 | 142.9 | 0.004 | 5.2 | 0.333 |
 mir-421 | MI0003685 | mir-95 | MIPF0000098 | 15.5 | 30.3 | 95.6 | 0.020 | 9.0 | 0.725 |
 miR-660-5p | MIMAT0003338 | mir-188 | MIPF0000113 | 196.9 | 99.7 | −49.4 | 0.028 | −10.2 | 0.451 |
 mir-671 | MI0003760 | mir-671 | MIPF0000358 | 14.8 | 44.4 | 200.0 | 0.003 | 4.2 | 0.692 |
 mir-3615 | MI0016005 | mir-3615 | MIPF0001540 | 50.1 | 78.3 | 56.4 | 0.031 | 1.3 | 0.881 |
 mir-3676 | MI0016077 |  |  | 2.1 | 11.1 | 437.1 | 0.027 | 12.9 | 0.218 |