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Table 3 Most consistently changed miRNAs in AUD

From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain

Symbol RNA-seq Microarray
miRBase acc# miRBase family MiRBase fam acc # Ctrl RPM AUD RPM % Δ AUD P-value % Δ AUD P-value
Tier A: RNA-seq p < 0.05, Array p < 0.1, consistent % Δ AUD
 mir-96 MI0000098 mir-96 MIPF0000072 4.6 11.3 142.6 0.031 15.0 0.059
 mir-320b-1 MI0003776 mir-320 MIPF0000163 61.0 144.6 137.1 0.004 22.2 0.071
 mir-1976 MI0009986 mir-1976 MIPF0001633 4.1 9.9 138.1 0.039 24.1 0.081
Tier B: RNA-seq p < 0.05, consistent % Δ AUD
 mir-24-1 MI0000080 mir-24 MIPF0000041 31.3 90.5 189.4 0.008 6.2 0.338
 mir-30a MI0000088 mir-30 MIPF0000005 108.2 209.9 94.0 0.014 5.1 0.860
 mir-92b MI0003560 mir-25 MIPF0000013 7141.9 4553.8 −36.2 0.016 −8.2 0.312
 miR-96-5p MIMAT0000095 mir-96 MIPF0000072 111.7 252.0 125.5 0.018 8.0 0.455
 mir-127 MI0000472 mir-127 MIPF0000080 68.6 158.9 131.5 0.021 8.4 0.455
 mir-136 MI0000475 mir-136 MIPF0000099 4.4 9.7 121.2 0.035 1.5 0.760
 miR-301a-3p MIMAT0000688 mir-130 MIPF0000034 205.9 85.1 −58.7 0.045 −2.4 0.878
 mir-320b-2 MI0003839 mir-320 MIPF0000163 61.3 148.8 142.9 0.004 5.2 0.333
 mir-421 MI0003685 mir-95 MIPF0000098 15.5 30.3 95.6 0.020 9.0 0.725
 miR-660-5p MIMAT0003338 mir-188 MIPF0000113 196.9 99.7 −49.4 0.028 −10.2 0.451
 mir-671 MI0003760 mir-671 MIPF0000358 14.8 44.4 200.0 0.003 4.2 0.692
 mir-3615 MI0016005 mir-3615 MIPF0001540 50.1 78.3 56.4 0.031 1.3 0.881
 mir-3676 MI0016077    2.1 11.1 437.1 0.027 12.9 0.218
  1. RNA-sequencing of human serum samples determined miRNAs with nominally significant alterations and trends in patients with AUDs. Comparison with microarray data subsequently identified changes that were consistent across platforms. MicroRNAs were classified into two tiers based on concurrence of both analyses. Where available, microRNA families for each miRNA are also listed. Note that these are nominal (uncorrected) p values
  2. RPM normalized reads per million