Fig. 2From: Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brainMicroRNAs in serum are in mature form. a Representative image showing RNA-seq reads aligned to region on chromosome 13. Reads are concentrated on mature miRNA chromosome coordinates as defined by the miRBase 20 database. b Trend plots mapping reads across all precursor miRNAs in the human genome show that reads are concentrated in regions that roughly correspond to mature miRNAs (-5p or -3p regions). We point out that the data shown are merely illustrative of the alignments produced during analysis of the RNA-Seq reads. Note that mature miRNAs are derived from the same strand as the full-length precursor, and appear in the location specified by the -5p box or -3p box. Also note that while the absolute levels of some mature miRNAs appeared to differ between AUD and Control subjects, the pattern of -5p or -3p usage appeared to be highly similar, which is best appreciated for the entire set of data in the lower plot Back to article page