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Table 1 UbcM2 expression is decreased in the neurons of specific substructures of the mouse brain

From: Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons

Brain structure Relative UbcM2 expression UbcM2 expression % change in aged mice P value
CA1 0.776 −11.518 0.0590
CA2 0.711 −9.714 0.1500
CA3 0.801 −7.614 0.1800
Caudate putamen 0.553 −6.471 0.4500
Cerebellum-granule layer 0.951 −14.530 0.0032
Cingulate ctx 0.679 1.317 0.8900
Dentate gyrus 0.630 1.806 0.8100
Facial nu 0.955 1.957 0.6900
Hypothalamus-lateral 0.919 6.637 0.1800
Inferior colliculus 0.687 −7.692 0.2800
Motor ctx-primary 0.951 −11.111 0.0260
Motor ctx-secondary 0.984 −5.372 0.2600
Nucleus accumbens 0.634 −7.051 0.3500
Olfactory nu 0.927 −10.526 0.0410
Pontine nu 0.976 7.083 0.1400
Reticular formation-lateral 0.976 −0.917 0.8500
Sensory ctx-primary 0.825 −10.837 0.0560
Spinal trigeminal nu 1.000 −8.943 0.0600
Superior colliculus 0.699 −14.535 0.0320
Thalamus-laterodorsal 0.789 −3.247 0.5800
Thalamus-ventral 0.720 −0.847 0.9000
Visual ctx-secondary 0.923 −11.454 0.0290
  1. The expression levels of UbcM2 in the brains of young and aged mice were measured and compared by average cellular α-UbcM2-derived fluorescence intensity in NeuN-positive nuclei. A 5.5 % global decrease of UbcM2 expression was detected in aged versus their strain-matched, younger counterparts. The italic numbers indicate decreases of UbcM2 expression of 10 % or greater in particular substructures of the brain