Fig. 4

Abolition of post-compression tactile sensibility following Cav3.2 blockade in glabrous skin. Monofilament detection thresholds (mN) were measured in the proximal (prox) and distal (dist) phalanges of the little finger (D5) prior to and following compression (comp) of myelinated fibres and treatment with T-type calcium channel antagonist, TTA-A2. The data are presented as a box-and-whisker plot. While all participants could detect low-force monofilament contacts in the compression condition, the subsequent blockade of Cav3.2 channels in glabrous skin abolished their capacity to detect monofilament contacts across the innocuous range (up to ~20 mN)